|Breed(s):||Chinook, Karelian Bear Dog, Norwegian Elkhound|
Chondrodysplasia is an inherited disease affecting dogs. Affected dogs are unable to synthesize a protein important for cartilage and bone development resulting in dwarfism. Symptoms can include short bowed legs, shortening of outer digits, “knock-knee” appearance, hip dysplasia and muscle Atrophy of hind limbs. On average, limbs of affected adults are about 10 cm shorter than normal dogs. Due to abnormal bone alignment at joints, dogs with this condition may be predisposed to arthritis as they age.
Genetic testing of the ITGA10 gene will reliably determine whether a dog is a genetic Carrier of chondrodysplasia. Chondrodysplasia is inherited in an Autosomal Recessive manner in dogs meaning that they must receive two copies of the mutated gene (one from each parent) to develop the disease. In general, carrier dogs do not have features of the disease but when bred with another carrier of the same Mutation, there is a risk of having affected pups. Each pup that is born to this pairing has a 25% chance of inheriting the disease and a 50% chance of inheriting one copy and being a carrier of the ITGA10 gene mutation. Reliable genetic testing is important for determining breeding practices. In order to eliminate this mutation from breeding lines and to avoid the potential of producing affected pups, breeding of known carriers to each other is not recommended. Dogs that are not carriers of the mutation have no increased risk of having affected pups.
There may be other causes of this condition in dogs and a normal result does not exclude a different mutation in this gene or any other gene that may result in a similar genetic disease or trait.
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